'Tumors Melted Away': What the year's biggest story in cancer really means for cancer patients.

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In June 2022, the New York Times published an article about a remarkable cancer study.

All 18 people in the study had their tumors melt away. A 100% response rate.

They are still being monitored, but as of right now, the cancer has not returned. They have avoided surgery and chemotherapy completely.

The patients in this study had a number of things in common:

- They all had been recently diagnosed with rectal cancer
- They all had not yet received treatment
- They all had  MSI-H/MMR (we cover what this is)
- They all received a Checkpoint Inhibitor drug on the trial
- This trial will likely lead to other clinical trials like it for other cancer types.

Listen as we talk about what this could mean for other cancer patients.  


New York Times article: https://www.nytimes.com/2022/06/05/he...

New England Journal of Medicine Study: https://www.nejm.org/doi/full/10.1056...

Clinical Trial (NCT04165772): https://clinicaltrials.gov/ct2/show/N...

Drug (dostarlimab): https://go.drugbank.com/drugs/DB15627

Category of Drug (immune checkpoint inhibitor): https://go.drugbank.com/categories/DB...


0:00 Intro

0:41 The Rise of Immunotherapy and Checkpoint Inhibitors

4:26 The Patients on the Study (Focus on Genetics)

6:10 What is MSI-High (or microsatellite instability) and how do you find out if you have it?

12:38 What is tumor sequencing (nextgen sequencing) and how do you get it?

15:35 Genetics and Genomics

19:12 Considering Immunotherapies Earlier (one step earlier than adjuvant therapy) - the surprising finding.

22:35 Dostarlimab (PD-L1Checkpoint Inhibitor) - what is worked and how do talk to your doctor about this class of drug.

27:29 What Does Sagely Health Do?