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Brain and CNS tumors

Phase I Study: Safety and Feasibility of IL-8 Receptor Modified CD70 CAR T Therapy in pHGG

Trial ID
NCT06946680 on ClinicalTrials.gov
Cancer type
Brain & CNS Tumors
Published in
New in Oncology - May 14, 2025

University of Florida is assessing the safety and feasibility of autologous, IL-8 receptor (CXCR2) modified CD70 CAR T cells in pediatric high-grade gliomas, with dose escalation across three cohorts (1x10^6, 1x10^7, and 1x10^8 cells/kg).

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