Phase 1 Trial: HistoSonics Histotripsy (ultrasound cavitation tissue ablation) in advanced colorectal metastases

Investigating whether combining histotripsy with standard palliative chemotherapy improves progression-free survival in patients with unresectable, bilobar colorectal liver metastases, this prospective, single-arm Phase 1 study at Cleveland Clinic and Case Comprehensive Cancer Center evaluates standard chemotherapy alongside histotripsy treatment, with supportive imaging, biopsies, and genetic testing to assess safety and potential enhanced clinical outcomes.