New trial
Phase 1 AB821 trial of CD8-targeted IL-21 immunotherapy.
- Trial ID
- NCT07027488 on ClinicalTrials.gov
- Cancer type
- Other Solid Tumors
- Stage of research
- First-in-human
- Published in
- New in Oncology - July 3, 2025
This open-label, dose-escalation study at Yale University in New Haven evaluates AB821 monotherapy given every 2 weeks in adults with recurrent, locally advanced or metastatic melanoma and other immune-responsive solid tumors, including NSCLC. It is a first-in-human trial assessing safety, pharmacokinetics, pharmacodynamics, immunogenicity, and preliminary antitumor activity.
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