New trial
Phase I trial of ulixertinib, an ERK1/2 inhibitor, with palbociclib, a CDK4/6 inhibitor.
- Trial ID
- NCT03454035 on ClinicalTrials.gov
- Cancer type
- Solid Tumors
- Published in
- New in Oncology - June 16, 2025
This phase I open-label study by UNC Lineberger evaluates safety, MTD, and RP2D of ulixertinib plus palbociclib in patients with advanced solid tumors and refractory melanoma. The trial includes dose escalation and expansion cohorts in metastatic pancreatic cancer and RAS-mutant, NF1-mutant melanoma.
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