Asked by
LW
QUESTION

Epenymomas and can no longer walk. What kind of success have you seen with bevacizumab and immunotherapy in general?

I have multiple brain/spine ependymomas. What kind of success have you seen with bevacizumab and immunotherapy in general? I just found out that the third chemo I’ve been on isn’t working. I’ve done surgeries, radiation, temozolomide, Etoposide, carboplatin.

RESPONSE FROM DR. SAGER
Dear
LW
,

Sorry to hear about your situation. Bevacizumab has more of a proven record than immunotherapies, but I would seek to do both, in combination if possible. I see trials like this one: https://www.clinicaltrials.gov/ct2/show/NCT03532295 that combines bevacizumab and immunotherapy (along with some other treatments).

There are also some newer CAR-T immunotherapies to target ependymoma (https://www.clinicaltrials.gov/ct2/show/NCT04661384).

Best Wishes,
Jason Sager, MD