New trial
Phase II: Trastuzumab (HER2-directed mAb) trial combining surgery, radiation, and SBRT for HER2+ breast cancer
- Trial ID
- NCT07053085 on ClinicalTrials.gov
- Cancer type
- Breast Cancer
- Stage of research
- Exploratory
- Location
- 7 Locations
- Published in
- New in Oncology - July 25, 2025
This randomized study assesses whether adding surgery, locoregional radiation therapy, and SBRT to standard systemic treatment (trastuzumab, a HER2-directed antibody; pertuzumab, another HER2 inhibitor; and paclitaxel, a microtubule inhibitor) improves outcomes in patients with de novo oligometastatic, resectable HER2+ breast cancer. The study evaluates safety and efficacy at Memorial Sloan Kettering Cancer Center.
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