New trial
Phase 1 trial: Mezigdomide (cereblon E3 ligase modulator) & Talquetamab (GPRC5D/CD3 bispecific mAb)
- Trial ID
- NCT07032714 on ClinicalTrials.gov
- Cancer type
- Multiple Myeloma
- Stage of research
- Exploratory
- Location
- 3 Locations
- Published in
- New in Oncology - Aug 1, 2025
This study by Massachusetts General Hospital evaluates optimal dosing and scheduling of mezigdomide and talquetamab in patients with relapsed/refractory multiple myeloma after four or more therapies. Two sequential cohorts assess different combination regimens with dexamethasone, employing a step-up dosing strategy to determine safety and early signs of efficacy.
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