New trial
Phase 1 vvDD-hIL2: Oncolytic vaccinia virus with IL2 expression
- Trial ID
- NCT07001592 on ClinicalTrials.gov
- Cancer type
- Upper GI Cancer
- Stage of research
- First-in-human
- Published in
- New in Oncology - July 3, 2025
This Phase 1 study evaluates vvDD-hIL2 administered via intra-tumoral injection to determine optimal dose and safety in patients with metastatic gastrointestinal and peritoneal tumors (MSI-H and MSS) at AHN West Penn Hospital. The trial advances oncolytic immunotherapy using a genetically modified vaccinia virus expressing IL2 in a three-dose escalation design at Allegheny Singer Research Institute.
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