Phase II Tumor-Focused Radiotherapy: Image-Guided Brachytherapy Radiation Device Targeting Prostate Cancer

The University of California, San Diego is conducting a phase II randomized trial comparing standard whole-prostate radiotherapy with investigational image-guided tumor-focused radiotherapy using a brachytherapy radiation device in intermediate- and high-risk prostate cancer patients planning definitive treatment. The study assesses whether targeting tumor foci can lower radiation exposure to nearby organs, potentially reducing acute genitourinary and gastrointestinal toxicity while evaluating survival, quality of life, and predictive biomarkers.