New trial
Phase I Study: BAFF CAR-T Cells (LMY-920) in Relapsed/Refractory CLL
- Trial ID
- NCT06916767 on ClinicalTrials.gov
- Cancer type
- Hematological Cancers
- Published in
- New in Oncology - May 14, 2025
Cleveland Clinic is investigating BAFF-ligand CAR T cells (LMY-920) following B-cell depletion with obinutuzumab, along with cyclophosphamide and fludarabine, in heavily pre-treated CLL patients to overcome resistance seen with CD19-targeted therapies.
More in other blood cancers and transplant
-
Trial result · Aug 13, 2026 · NCT04904588
Standard-dose PTCy enables mismatched-donor HCT but carries substantial early infection burden -
Trial result · Aug 6, 2026 · NCT05388123
Low-dose vemurafenib (BRAF V600E inhibitor) + rituximab drives 73% CR with zero grade 3-4 AEs in HCL -
Trial result · Aug 6, 2026 · NCT02113982
Tagraxofusp (CD123-directed cytotoxin) in BPDCN delivers 71%–90% ORR across trials—HSCT bridge drives survival -
New trial · Jun 25, 2026 · NCT07634536
Phase 2 automated VMAT-based TMLI conditioning refines marrow / lymphoid-targeted irradiation for allo-HCT. -
New trial · Jun 25, 2026 · NCT07572006
Phase 1 JNJ-95804306 (no disclosed MOA/target) in relapsed/refractory AML/MDS and CLL/SLL