New trial
Phase 2 WU-CART-007: CD7-targeted CAR-T Cell Therapy for R/R T-ALL and T-LBL
- Trial ID
- NCT06514794 on ClinicalTrials.gov
- Cancer type
- Hematological Cancers
- Stage of research
- Registrational
- Location
- 7 Locations
- Published in
- New in Oncology - July 11, 2025
This trial evaluates the efficacy of a single intravenous infusion of WU-CART-007—an anti-CD7 CAR-T cell therapy administered after lymphodepletion—in relapsed or refractory T-cell acute lymphoblastic leukemia and lymphoblastic lymphoma patients. Sponsored by Wugen, Inc., the study aims to assess composite complete remission and minimal residual disease-negative response, offering new insights into targeting CD7 in these aggressive malignancies.
More in other blood cancers and transplant
-
Trial result · Aug 13, 2026 · NCT04904588
Standard-dose PTCy enables mismatched-donor HCT but carries substantial early infection burden -
Trial result · Aug 6, 2026 · NCT05388123
Low-dose vemurafenib (BRAF V600E inhibitor) + rituximab drives 73% CR with zero grade 3-4 AEs in HCL -
Trial result · Aug 6, 2026 · NCT02113982
Tagraxofusp (CD123-directed cytotoxin) in BPDCN delivers 71%–90% ORR across trials—HSCT bridge drives survival -
New trial · Jun 25, 2026 · NCT07634536
Phase 2 automated VMAT-based TMLI conditioning refines marrow / lymphoid-targeted irradiation for allo-HCT. -
New trial · Jun 25, 2026 · NCT07572006
Phase 1 JNJ-95804306 (no disclosed MOA/target) in relapsed/refractory AML/MDS and CLL/SLL
