TCR α/β Depleted PBSC Transplantation in Inherited Bone Marrow Failure Disorders

This phase II trial at the Masonic Cancer Center investigates T cell receptor α/β depletion in PBSC transplantation for patients with inherited bone marrow failure syndromes, aiming to eliminate routine GVHD prophylaxis and promote faster immune recovery while reducing infection risk. Various conditioning regimens tailored to donor type and patient characteristics underscore the trial’s potential to optimize transplant outcomes for both pediatric and adult MDS and aplastic anemia cases.